csgo monetization

Is it possible to earn money from csgo, if possible, how to do it by opening a safe?

It is possible yes, with random drops you get from csgo, you can start by selling most of them or use 3rd party sites to trade your multiple skins for better ones, you can gamble them, you can try to upgrade them, endless options.
Sadly, the whole gambling/betting scene was killed because of a kid who used his parents credit card to bet tons of money and lost it... It was the most proffitable way.