The problem at the beginning is that it has tons of items, mechanincs, characters and names you'll have to remember, added to the point that each character has own mechanics, so in order to win you'll need to understand: the mechanics of your character, the mechanics of your enemy, the mechanics of your own team and the mechanics of the game in general. When you start playing that can be overwhelming, but the game is so fun that you won't bother on losing or winning your firsts games. Practice will make you master it.
On the other hand, I've spent soo much time playing LoL. I wish I had never started xD