Yes, you can even have 4-CPU motherboards. I built a server using a Tyan, dual-Xeon motherboard, and it has been very responsive for years. When you build a dual-cpu computer, you need to make sure that the "stepping" of the CPU's is the same, and also, of course that the CPU's are multiprocessor capable. It's challenging, but a lot of fun to build a multiprocessor computer (it's really called a workstation or a server, when you're creating such a build). Here's a tip: Try to get a case that allows the motherboard to lie horizontally. The heatsinks on dual-CPU configurations are best when they are big and copper. That means that they're heavy. If you have a vertically-oriented motherboard, that can put a lot of stress on the CPU mounts. Keeping things horizontal spreads the weight of the heatsinks, and puts a lot less stress on the motherboard.