All four monitors are used all the time. I like spreading things out.
Not streaming: Left monitor = Web browsing / twitch / forum / emails Main monitor = usually videos / gaming/ Photoshop/gimp when using them Top screen, TS , steam friends right screen = Steam library, more web browsings / more twitch feeds w/e
Streaming: Left monitor twitch desktop Top, OBS, ts, and steam friends list Main = Game Right= Ankh Bot (twitch mod bot), Chatty (irc), TwitchAlerts