Almost never again, I remember as a child when we got GTA:VC or SA, we didn't event think of playing without cheats, that was the way of playing it for us, cheats were there to have fun and I didn't even understood the plot anyway so I didn't care. Now I like challenges and try not to ruin the the experience.
And cheating in MP would be a big no for me except when I'm playing "tes3mp" coop with my cousin, we always end up finding a bug by accident and exploiting it (there were a lot due to syncing issues), anyway I had already beaten the game many times, it's a good way of replaying it.