ECMAScript 6 in production

Do you use ES6 in production code? Or do you use transpilers? We can be so and write at all in ES5.1 syntax (as I )

For sure, ES2015 in node and using babel as transpiler/compiler. Wouldn't throw ES2015 and newer out to the browsers quite yet

I Use Angular 4 with TypeScript and because TypeScript is a SuperSet of ES6 i use most of the ES6 features, in a sense I am using Transpiler.