As for me, I find it disgusting to see my girl sleeping with another guy. I've never been in this kinda situations before, but just knowing this fact will make me act instantly.
RE: What would you consider a significant reason to instantly end up relationships?
Intimate discussions with a guy other than me, sharing me naked with her friends on her phone, sleeping with a guy, stealing, insulting my family, abusing kids or animals, freeloading... to name a few